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however, the same effect has not been replicated in large-scale human or primate studies [49]

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One possible cause for such controversy might be the substance-specific effects of saxagliptin, which could be attributed to off-target side effects of DPP4 enzyme, resulting in unexpected alterations of other bioactive substrates in the body

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Recent evidence suggests that GLP-1 receptor agonists (GLP-1 RAs) can significantly improve physical activity limitations and exercise capacity in obese patients with HFpEF

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Regulation of Na + /H + exchanger NHE3 by glucagon-like peptide 1 receptor agonist exendin-4 in renal proximal tubule cells

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