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Weight loss is starting but not yet dramatic

The initial decrease in body weight is the result of two major effects of SGLT2 inhibition: caloric loss due to glucose excretion (a process also called calorie restriction mimicry) and loss of body water due to osmotic diuresis

Introduction Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP1-RAs), also known as GLP-1 analogs, are synthetically produced recombinant polypeptides that mimic the activity of GLP-1

Relative contraindications or situations requiring heightened caution include severe gastroparesis, active gallbladder disease, history of pancreatitis, severe gastrointestinal disease, diabetic retinopathy, and inadequate nutritional status

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