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Retatrutide for Metabolic Research Retatrutide for Metabolic Dysfunction-Associated Research Retatrutide is currently being investigated for research involving: Obesity Metabolic dysfunction-associated steatotic liver disease Glycemic control Endocrine signaling Weight management Multiple metabolic pathways Triple-Hormone-Receptor Agonist Retatrutide for Obesity Research involving receptor agonist retatrutide for metabolic dysfunction-associated conditions has gained significant interest because the peptide influences: GLP-1 receptor pathways GIP receptor signaling Glucagon receptor activity Energy expenditure Appetite regulation Several phase 2 trial studies involving obesity and glycemic control demonstrated promising metabolic outcomes

Acknowledgments Sushma Soni, CMPP, of inScience Communications, Springer Healthcare (Philadelphia, Pa.), and Amy Zannikos, PharmD, CMPP, on behalf of inScience Communications, Springer Healthcare, provided medical writing support, which was funded by AstraZeneca

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There is no confirmed approval date

Additionally, the risk of hospitalization for heart failure with GLP-1 RA therapy in participants receiving and not receiving SGLT2 inhibitors at baseline was similar (HR 0.58