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Human GPR17L, hGPR17S, and mGPR17 were expressed in HEK293 cells, and cAMP signaling modulation was measured following treatment with indicated concentrations of MDL29,951 and cAMP stimulation with forskolin (Figure S3 and Table S1)

However, patients should distribute fluid intake throughout the day rather than consuming large volumes at once, and consider reducing intake 23 hours before bedtime to minimize nocturia

Brietzke E, Kapczinski F, Grassi-Oliveira R, Grande I, Vieta E, McIntyre RS

Hayes JD, Dinkova-Kostova AT (2014) The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Diabetes Obes Metab (2017) 19(9):120513

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