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Pair Retatrutide (triple GLP-1/GIP/glucagon agonist) with MOTS-C (mitochondrial-derived peptide) to investigate multi-receptor metabolic signalling and cellular energy regulation.

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It works by increasing levels of key brain chemicals like norepinephrine, dopamine, and serotonin, which can help suppress appetite, reduce emotional eating, and support sustained daily energy.

The first randomised controlled trial of semaglutide for alcohol use disorder, published in JAMA Psychiatry in 2025, found that people taking low doses had fewer heavy drinking days, fewer cravings, and reduced alcohol intake compared to placebo