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Liraglutide, an acylated GLP-1 analogue, extends its half-life to 1214 h via binding to albumin [71, 72]

GLP-1 also protects cells of the cardiovascular and nervous systems by reducing inflammation and apoptosis

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Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise ( Dosing schedule and route have also been identified a major factor affecting compliance with a single weekly injection achieving just over 10% lower risk of discontinuation (Weeda et al., 2021)

Vitam Horm (2022) 118:45778

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