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This is known as insulin resistance
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The Transition of Acute Postoperative Pain to Chronic Pain: An Integrative Overview of Research on Mechanisms

Small studies suggest that very little, if any, injectable semaglutide (Ozempic, Wegovy) or tirzepatide (Mounjaro, Zepbound) passes into breast milk

doi: 10.1210/jcem.86.5.7463 [DOI] [PubMed] [Google Scholar] 197

A: Current studies suggest they may reduce the risk of depression, but they are not approved as depression treatments
