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In addition, preclinical and clinical data were used to study the potential effects of drugs with multiple agonists and pathways through which gut-brain signaling pathways can be used to promote sustained weight loss without side effects
295 , R459R462 (2008)
Most people if they have not addressed the underlying cause of the weight gain will gain the weight back
So, is there real cause for concern
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This, in turn, compromises efficacy and limits long-term adherence
