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ACKNOWLEDGEMENTS We thank Diana Williams, David Hodson and Marie Holt for their critical comments on this manuscript

households include a GLP-1 user, implying these emerging food preferences are impacting about one out of every four consumers

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In vivo imaging revealed no significant difference in barin fluorescence intensity between the fasting mice and normal mice, further confirming that ITP-mediated brain targeting is independent of insulin-induced IR endocytosis in vivo (Supplementary Fig
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