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Mass Modification of Archived Data: All study folders on the archivist's hard drive were found to have been "modified on or about January 5, 2025, shortly prior to the inspection".11 This mass modification of electronic records immediately before an inspection is a classic indicator of data manipulation (or a clumsy attempt at organization that destroyed the original timestamps)

We expect the commercial roll-out to follow a similar path to previous launches in this class: Commercial List Price (WAC): The retail cash price is expected to land between $1,000 and $1,500 per month

While these clinical studies documented only moderate and heterogeneous effects of GLP-1RAs on lean body mass, rodent studies have demonstrated a reduction of visceral adipose tissue and upregulation of browning-related genes in subcutaneous white adipose tissue, which can lead to a stimulation of energy expenditure by upregulated thermogenesis [79, 109, 110]

This study echoes that insurance barriers (and lack of coverage) suppress GLP-1 uptake: all patients had insurance, yet 40% of scripts were never filled ( [30] )