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Informative on the new anti-obesity GLP-1MK-801 conjugate from @OdgaardJonas @BueKlein and @ClemmensenC Lab Targeting to specific cell types in the brain is challenging, but this new paper uses a bifunctional molecule that delivers an NMDA receptor antagonist to GLP-1 receptor expressing neurons in an effort to treat obesity

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10.1016/j.jacc.2019.07.081 J

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Your body adapts to semaglutide, and weight loss naturally slows as you approach a new set point