glp-1 dosing chart tirzepatide Dosage Guide and for Weight Loss Tirzepatide (MOUNJARO®/ZEPBOUND) vs Semaglutide (OZEMPIC®/WEGOVY®)

95% CI, 1.112.78

Considering the prolonged half-life of most GLP-1 agonists currently prescribed, it is unfeasible to withhold these agents for weeks prior to surgery to achieve normalisation of gastric function with unknown impact on aspiration rates, appreciating the detrimental effects of poorer glycaemic control on withholding these agents and associated higher risk of peri/postoperative complications (major cardiovascular events, poor wound healing, increased wound infection etc.)

Several other trials are assessing the safety and efficacy of tirzepatide in improving different cardiometabolic complications such as OSA, MASH and heart failure with preserved ejection fraction (HFpEF) (NCT05412004, NCT04166773, NCT 04847557) [16]

My biggest concern with weight loss in a pill (or, in this case, an injection) is that people will no longer be hungry for the nutrients they need

Researchers are still studying the differences between medications like: Semaglutide Tirzepatide Liraglutide Tirzepatide often leads to more overall weight loss

"Based on accumulated evidence, it does not seem like GLP-1 drugs when used during the months after conception increase the risk of common (adverse) outcomes substantially