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GLP-1 receptor agonists commonly cause diarrhea due to delayed gastric emptying, increased intestinal transit time, altered gut microbiota composition, and p...

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Although canonically GLP1Rs signal through the stimulatory alpha Gs protein, we find that semaglutide utilizes both Gs- and Gq-signaling pathways in GLP1Rs in the area postrema (AP)the primary site of semaglutide action in the brainto differentially regulate neuronal activation across distinct neuronal clusters