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Tirzepatide demonstrated approximately 5-fold lower affinity at the GLP-1 receptor compared to native GLP-1, and 20-fold lower potency in cellular signaling compared to semaglutide

These are not voluntary guidelines

[1] [2] Your provider may evaluate whether dose adjustment according to the FDA-approved titration schedule is appropriate based on your response and tolerance

The side effects linked to Mounjaro are consistent across all dose strengths

Thyroid tumor risk: Individuals with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should avoid tirzepatide due to the risk of thyroid tumors

The prescribing information for Ozempic states: "Pancreatitis has been reported in the clinical trials