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In conclusion, compound 20 in the biphenyl-substituted triazole group, as well as compounds 21 and 22 in the acetoxy- and monophenyl-substituted triazole groups, demonstrated the highest potency for inhibiting DPP-4 (99) (Figure 4)

Despite these approaches, PH remains a complex and often underrecognized complication, underscoring the need for further research

Similarly, sudden onset of jaundice (yellowing of skin or eyes), dark urine, or pale stools suggests possible bile duct obstruction requiring urgent assessment

Starting with lower doses and gradually increasing helps minimize these effects

But there is a clinical question receiving far less attention, one that matters enormously to the individuals and families we work with at SpringSource every day