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Therefore, the research and development of the relevant drugs and the replacement therapy of double GIP-GLP-1R agonists (e.g., tirzepatide) and triple GIP-GCG-GLP-1R (e.g., peptide 20) agonist are key research fields

Presented data on combination therapies at the 2025 ADA meeting, exploring synergistic effects with other metabolic agents

Yaghoubi, A., Amel Jamehdar, S., Reza Akbari Eidgahi, M

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doi: 10.3389/fphar.2023.1228722 Received 25 May 2023 Accepted 26 June 2023 Published 04 July 2023 Volume 14 - 2023 Edited by Aliyu Muhammad, Ahmadu Bello University, Nigeria Reviewed by Abdurrahman Pharmacy Yusuf, Federal University of Technology Minna, Nigeria Kang-Hoon Kim, Monell Chemical Senses Center, United States Updates Copyright 2023 Wu, Xia, Guo, Wang, Dong, Lu and Yuan

A 2021 New England Journal of Medicine study found that combining semaglutide with lifestyle interventions, including exercise, led to an average 14.9% weight loss over 68 weekssignificantly more than lifestyle changes alone