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ADEs: adverse drug events

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[2] [3] Similarly, in the SURMOUNT trials for weight management, Zepbound's label reports gastrointestinal events as the most common adverse reactions, with nausea (24-30%), diarrhea (18-23%), vomiting (8-12%), and constipation (11-17%) occurring at somewhat higher rates than in diabetes trials

Gout There are some limited studies in patients with gout, some reporting a possible flare of gout when therapy with GLP1 is started, mostly due to rapid weight loss and dehydration that may precipitate gout attacks
