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35 One of the most attractive features of GLP-1 drugs is that they shut off the food noise so many people experience that makes staying in a caloric deficit or even just changing food preferences so difficult

In PIONEER 6 trial, 3183 patients with T2DM were randomized to either oral semaglutide or placebo were observed for cardiovascular events up to a median of approximately 16 months

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While these medications primarily reduce fat body mass (FBM), loss of lean body mass (LBM) can also occur, raising concerns about muscle loss in susceptible populations, such as frail individuals and older adults

thyroid cancer or hyperthyroidism, gastroparesis, pancreatic cancer or pancreatitis, MEN2 syndrome, or inflammatory bowel disease)

It is typically the first-line agent prescribed when a patient is newly diagnosed with type 2 diabetes