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Exenatide versus metformin in obese PCOS women with prediabetes: A randomized controlled trial

A 2025 study published in JAMA Network Open found that most patients with obesity discontinue GLP-1 therapy within a year, particularly those without type 2 diabetes 1

Meta-analyses suggest modest improvements in depression scores and quality-of-life measures, but causality remains unclearbenefits may reflect weight loss, improved metabolic health, or direct neural effects

Even if a patch were made with actual semaglutide, research shows the skin stops it from entering the body

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21,22 Although clear protective benefits in diabetic retinopathy development and impact on disease progression remain under investigation, GLP-1RAs have been shown to reduce complications from chronic diabetes, such as retinal vein occlusion and cardiovascular disease