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The practical advice outlined in this article should help GPs to prescribe GLP-1RAs safely and effectively and ensure patients benefit from these new potent and multifaceted agents

Healthcare professionals should also monitor for adverse effects, particularly gastrointestinal symptoms

Alcohol consumption can impair the liver's ability to produce glucose through gluconeogenesis, especially during fasting states or several hours after drinking

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Within a structured, monitored program, clinicians sometimes combine agents that work through different mechanisms a stimulant appetite suppressant and a GLP-1 agonist act on entirely separate pathways, so the rationale for layering them is coherent