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While expensive relative to other agents, these classes of drugs are generally cost-effective as second-line treatment, although cost-effectiveness data are limited

An initial analysis of the FDA adverse event reporting system (FAERS) data demonstrated no consistent trends in DKA with SGLT2i use over time [39], however an alternative cohort study of 50,220 individuals with type 2 diabetes showed the highest risk of DKA shortly after SGLT2i initiation, which subsequently reduced with time [40]

Preliminary clinical evidence supports this hypothesisstudies in obese individuals treated with tirzepatide have shown a downward trend in the apneahypopnea index (AHI), suggesting that tirzepatide may have a beneficial effect on sleep-disordered breathing (28)

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