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PMID:17306374

Quick Answer: Most patients require long-term GLP-1 therapy because diabetes and obesity are chronic conditions, and discontinuation typically causes weight regain and worsening blood sugar control

Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes

Maximally tolerated doses of background therapy were to remain unchanged for the duration of the trial

From the industrial trend of GLP - 1 drugs, the main R & D directions are oral small - molecule drugs and long - acting drugs

The second study looked at 635 patients with type 2 diabetes who were also overweight or obese