glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]
Description
I sincerely hope this is not an ominous sign for MS-Selfie and its subscribers
![glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]](https://tmedweb.tulane.edu/pharmwiki/lib/exe/fetch.php/glp1.png?w=600&tok=baf39c)
doi: 10.1016/j.jacc.2020.05.037 38 DaviesMJDAlessioDAFradkinJKernanWNMathieuCMingroneGet al
![glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]](https://www.nejm.org/cms/10.1056/NEJMcibr2409089/asset/1f854e14-bfd6-40e1-8b1c-03461c2a1ab4/assets/images/large/nejmcibr2409089_f1.jpg)
A phase 1b/2a trial of the weekly subcutaneous administration was conducted to assess safety, tolerability, pharmacokinetics and dose-related effects on body weight (83)
![glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]](https://media.springernature.com/full/springer-static/image/art%3A10.1038%2Fs41392-024-01931-z/MediaObjects/41392_2024_1931_Fig1_HTML.png)
But the crown wont go to the first to market
Many people are prescribed it privately for weight management due to promising clinical results
![glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]](https://www.thebusinessresearchcompany.com/_next/image?url=https%3A%2F%2Fd1lt5802h39cn9.cloudfront.net%2Fverticalimages%2FGLP_1_receptor_agonist_global_market_report_infograph_coverpage.webp&w=640&q=75)
Beyond these regions, relevant GLP-1 receptor populations have been identified in at least 10 additional brain areas, pointing to physiological roles that extend well beyond feeding
![glp-1 agonist history Reflections on the discovery as a satiety hormone: Implications for obesity therapy and future directions glp-1_analogs [TUSOM | Pharmwiki]](https://www.biochempeg.com/usr/uploads/3/202302/GLP-1-history.jpg)