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Mild GI side effects are common but manageable

Ozempic (semaglutide) and Wegovy are part of a newer class of GLP-1 drugs (glucagon-like peptide-1 receptor agonists)

doi: 10.1016/j.ophtha.2016.08.017

GLP-1 receptor agonist liraglutide has a neuroprotective effect on an aged rat model of Wolfram syndrome

Food intake regulation and signaling between the gut-adipose-brain axis are important targets for treatment of obesity.33 Historically, options for treatment of obesity focused on dietary modification and exercise.34 Many of the comorbidities associated with obesity can be effectively managed with a sustained 510% body weight loss, which is a reasonable first step for most patients.35 Bariatric surgical options, which result in more than 25% total body weight loss, are not widely adopted due to costs and side effect profile.36,37 Fortunately, there has been substantial expansion of pharmacological therapies for obesity in the last decade