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Identifying Abnormal Blood Clots in Blood Vessels Locations and Presentation: Deep veins: Swelling, tenderness, erythema, and warmth Superficial veins: Palpable cord, localized redness, mild discomfort Pulmonary arteries: Dyspnea, tachypnea, pleuritic chest pain Mesenteric or cerebral vessels (rare): Abdominal pain, neurological deficits Diagnostic cues: Positive Homans sign (pain in calf with dorsiflexion) supportive but not definitive Imaging such as Doppler ultrasonography for DVT or CT pulmonary angiography for PE Laboratory tests, including D-dimer, may indicate active clot formation Complications if untreated: Chronic venous insufficiency Pulmonary hypertension secondary to recurrent PE Risk of developing abnormal blood clots that can cause organ ischemia Unique Considerations in Women: Pregnancy and Hormonal Risks Pregnancy : Increases clotting factors, reduces fibrinolytic activity, and physically compresses veins, elevating risk of blood clots in women with factor v leiden

Routine monitoring of serum calcitonin or using thyroid ultrasound is of uncertain value for early detection of MTC in patients treated with Saxenda

Ongoing & Emerging Research Heart Failure with Preserved Ejection Fraction Status: Phase 3 Ongoing Focus: HFpEF outcomes in obese patients Timeline: Results expected 2025-2026 NASH/MASH Status: Phase 3 Ongoing Focus: Hepatic steatosis and fibrosis improvement Timeline: Multiple trials in progress Obstructive Sleep Apnea Status: Phase 3 Ongoing (SURMOUNT-OSA) Focus: OSA severity reduction with weight loss Timeline: Results expected 2024 Pediatric Obesity Status: Phase 3 Ongoing Focus: Weight management in adolescents (12 years) Timeline: Early-phase research Research Resources How to Find More Trials 1