soul trial oral semaglutide cardiovascular outcomes results 2024 2025 nejm and in Type 2 Diabetes SOUL (Semaglutide cardiOvascular oUtcomes triaL)

And you bear the consequences if something goes wrong

Personalized Medicine: The Role of Genetic Insight Individual responses to semaglutide vary partly due to genetic differences in how your body processes hunger signals and metabolizes medications

The authors were also explicitly aiming to quantify the potential benefits of these drugs in reducing peoples drug-related symptoms

Feel free to look up the evidence yourself

We speculate this could potentially explain the absence of reduced risk for PDAC associated with GLP1RA-related weight loss in contrast to weight loss following bariatric surgery 45

Using laxatives can make you feel skinnier, even though, as noted above, you arent really losing any actual body fat weight