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[DOI] [PMC free article] [PubMed] [Google Scholar] 74.Farokhnia M., Browning B.D., Crozier M.E., Sun H., Akhlaghi F., Leggio L

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Molecular durability is achieved through peptide engineering strategies that (i) confer resistance to DPP-4 cleavage, typically via N-terminal modification, and/or (ii) extend systemic exposure through fatty-acid acylation, which enhances albumin binding and slows renal clearance, thereby prolonging receptor activation [18]
