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Unlike other diabetes drugs that mimic just one hormone, tirzepatide activates two important hormone receptors : GLP-1 (Glucagon-Like Peptide-1) GIP (Glucose-Dependent Insulinotropic Polypeptide) These hormones help regulate blood sugar levels, but they also play a significant role in appetite control , digestion , and metabolism which is where the weight loss benefits come in

GLP-1 moves to the brain's hypothalamus and signals that you are full

What the Published Data Shows The STEP trials, which established semaglutide's efficacy for weight management , studied the drug at 2.4 mg weekly

2021: Wegovy, which is made up of the same active ingredient as Ozempic, is approved to treat weight loss

However, these symptoms can negatively affect treatment adherence, quality of life, and discontinuation rates, thereby impacting long-term treatment success

More serious but less common adverse effects require clinical vigilance