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Four reasons GLP-1s affect sleep Circadian rhythm disruption GLP-1 receptors in the hypothalamus modulate GABA, orexin, and melatonin, shifting sleep-wake cycles Blood sugar fluctuations Your body adjusts to new overnight glucose patterns, disrupting sleep cycles during adaptation Physical side effects Night sweats, digestive discomfort, and nausea peak during the first 46 weeks and dose escalation periods Psychological factors Adjusting to a new relationship with food and body image can trigger anxiety or racing thoughts at night Free Resource Get Dr

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For people interested in semaglutide dosing protocols , the standard titration schedule moves from 0.25mg weekly through 0.5mg, 1.0mg, 1.7mg, and finally 2.4mg, with each dose maintained for approximately four weeks before increasing