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doi: 10.1038/nm873

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Randomised clinical trials must come first

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Dose, duration, adherence, and changes in other medications over time are also important unanswered issues. Researchers say randomized clinical trials will be needed to confirm the findings and better understand how GLP-1 medications may affect cardiovascular risk in people with autoimmune diseases

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Retatrutide has a half-life long enough to maintain relatively stable plasma concentrations between weekly doses, avoiding the peaks and troughs associated with shorter-acting GLP-1 agonists administered daily

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