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doi: 10.1038/nm873

Randomised clinical trials must come first

Dose, duration, adherence, and changes in other medications over time are also important unanswered issues. Researchers say randomized clinical trials will be needed to confirm the findings and better understand how GLP-1 medications may affect cardiovascular risk in people with autoimmune diseases
Retatrutide has a half-life long enough to maintain relatively stable plasma concentrations between weekly doses, avoiding the peaks and troughs associated with shorter-acting GLP-1 agonists administered daily

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