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Anal fissures are small tears or cuts in the mucosal lining, a thin and delicate lining, of the anus
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Purpose of Review This review will summarize the most contemporary trials for glucagon-like peptide 1 receptor agonists (GLP1-RA) and sodium-glucose cotransporter 2 inhibitors (SGLT2-i) and present guidance on management and recommendations on adjunctive tapering of insulin in patients with insulin-dependent diabetes mellitus, which we term de-insulinization. Recent Findings GLP1-RA and SGLT2-i are the principal classes of diabetes medications evidencing cardiovascular benefit
People on GLP-1s had slightly higher risks of osteoporosis and gout than similar people not taking these drugs
A number of investigational new drugs targeting GLP-1R, GIPR and GDF-8 pathways are under clinical trials (Table 2)
