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(2) reduce clearance rate due to slowed metabolism and renal filtration (131)
That means food leaves the stomach more slowly and enters the small intestine in a more controlled way
Drug Discovery
Diabet Res Clin Pract 97:2742
For instance, replacing problematic functional groups, such as the carboxylic acid group in danuglipron, with alternative structures has shown promise
Leptin administration exacerbates thioacetamide-induced liver fibrosis in mice
