va glp 1 coverage So Upset with the right now over GLP-1 medications. : r/VeteransBenefits Costly GLP-1 Drugs are Rarely

Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide significantly decreases glycated haemoglobin compared with once-daily liraglutide in Japanese patients with type 2 diabetes: 52 weeks of treatment in a randomized phase III study

24 This can be due to differences in the specific drug used, the dosage, the duration of the study, the characteristics of the participants (age, baseline health) 9 , the methods used to measure body composition (DXA, BIA, MRI all have different strengths and weaknesses) 16 , and whether interventions like dietary counseling (especially protein emphasis) and exercise were included

In contrast, long-acting agonists (such as albiglutide or dulaglutide, or extended-release exenetide) have a stronger effect to reduce fasting glucose levels mediated by their effect on insulin and glucagon release

While it can be difficult to predict which factors will be most relevant in affecting commercial success from one product to the next, it is possible to observe sales trends and make pharmacoeconomic assessments within the current global GLP-1 market

Admittedly, these metabolic analyses were focused on the initial phase of treatments, as this period displayed the largest changes in body weight and is less likely affected by compensatory responses, which might confound the identification of primary mechanisms

We note that without information on peoples BMI and underlying medical risk factors, it is not possible to determine whether this reflects a genuine medical need