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The trial also flagged a new dose-dependent safety signal - dysesthesia, an abnormal nerve sensation such as tingling or burning - at 20.9% on the 12 mg arm, which will shape the label and the real-world dose pattern

Physical activity, while initially challenging when feeling fatigued, often proves to be energizing

Dose-response effects on HbA1c and bodyweight reduction of survodutide, a dual glucagon/GLP-1 receptor agonist, compared with placebo and open-label semaglutide in people with type 2 diabetes: a randomised clinical trial

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NOACs versus warfarin in people with atrial fibrillation and thyroid dysfunction

Neither group is listed prominently on current drug labels, and neither surfaced clearly in the major weight-loss trials