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Assessment of consistency across finngen, PGC, UKB, and other GWAS datasets with meta-analysis To evaluate the consistency of our findings across multiple independent datasets, we conducted Mendelian randomization (MR) analyses using summary genetic data from the FinnGen consortium (R9) ( Psychiatric Genomics Consortium (PGC, and UK Biobank ( The number of individuals included in these analyses ranged from 133,164 to 306,119, as detailed in Supplementary Table S2

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[DOI] [PMC free article] [PubMed] [Google Scholar] Sehgal R, Markov Y, Qin C, Meer M, Hadley C, Shadyab AH, Casanova R, Manson JE, Bhatti P, Crimmins EM, Hagg S, Assimes TL, Whitsel EA, Higgins-Chen AT & Levine M (2023) Systems Age: A single blood methylation test to quantify aging heterogeneity across 11 physiological systems