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Laboratory and early clinical studies suggest that GLP-1 receptor agonists may dampen reward-driven behavior and reduce the salience of addictive stimuli

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Biased agonism of GLP-1R and GIPR enhances glucose lowering and weight loss, with dual GLP-1R/GIPR biased agonism yielding greater efficacy

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Unlike Mounjaro, however, Zepbound is FDA-approved to support weight management for people living with obesity or overweight who have at least one weight-related condition, such as type 2 diabetes, high cholesterol, or hypertension (high blood pressure)

The specific parameters can be based on patientcentered shared decisionmaking, considering each person's stage and severity of disease, risk of progression, and comorbidities