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No class of medication has gotten more buzz in recent years than the glucagon-like peptide-1 (GLP-1) receptor agonist, better known by the brand names Ozempic, Wegovy, Zepbound or the generic name semaglutide or tirzepatide

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Clinical trials report eructation in approximately 2 to 5% of patients taking tirzepatide across the 5 mg, 10 mg, and 15 mg dose range

Genetic testing through the Precision Peptide Genetic Test ($99 add-on after first treatment month) identifies whether an athlete's FTO rs9939609 or GIPR rs1800437 variants predict a more conservative or responsive GLP-1 pathway

The most common side effect of GLP-1RAs is nausea and vomiting, which are hypothesized to result from inhibition of gastric emptying

Nauk et al, 2011