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My resting heart rate went up a little (enough for my Oura ring to notice) and my perceived effort during exercise was higher during the 3-4 days of highest effectiveness

Research indicates that GLP-1 receptor agonists, including semaglutide, do not suppress testosterone production or damage sperm directly, making them a viable option for men seeking sustainable weight loss without sacrificing reproductive capacity

It helps improve energy balance by increasing fat breakdown while decreasing fat storage, resulting in long term weight loss

Other glucose-lowering medications Metformin, when delivered intraduodenally, slows gastric emptying modestly in type 2 diabetes in the absence of nausea [56]

With respect to sex, female patients presented a more pronounced weight loss, which was statistically significant for the 3-month follow-up visit