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Tirzepatide is indicated an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial BMI of 30 (obesity) or 27 (overweight) in the presence of at least one weight-related comorbid condition (eg, hypertension, dyslipidemia, T2D, obstructive sleep apnea, or CVD)

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Brief periods outside refrigeration are not always catastrophic

To assess the influence of follow-up choices and potential informative censoring, we repeated analyses across alternative follow-up windows

Amylin is a neuropeptide co-secreted with insulin by pancreatic beta-cells which slows gastric emptying, and decreases food intake (84, 85)