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Le persone affette da disturbi epatici o renali dovrebbero consultare un medico prima di iniziare l'assunzione, dato il ruolo di alcuni ingredienti nel metabolismo epatico

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However, causality remains uncertain

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Modulating mitochondrial bioenergetics may be an effective treatment for HF since empagliflozin treatment significantly increased the myocardial ATP levels, myocardial mitochondrial complex I activity, and myocardial mitochondrial respiratory control ratio at 6 and 24 h after return of spontaneous circulation (ROSC) [119]