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The safety profile of tirzepatide was consistent with GLP-1 receptor agonists

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Mounting evidence implicates chronic neuroinflammation and glial cell dysregulation as central drivers of this neurodegenerative process [98100]

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Dose adjustments and titration protocol changes are normal parts of GLP-1 treatment management and can often address tolerability issues

The overall incidence of gastrointestinal adverse events was 11.66%, with nausea being the most frequent (21.49%) and reduced appetite the least frequent (5.49%)
