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It ebbed and reappeared again around week four, which makes sense from what we know of tirzepatides half-life (of approximately five days), as it takes roughly four to five weeks of regular dosing to reach a steady state in the body where drug levels stabilise at a consistently higher baseline than in the early weeks

Interestingly, weve had clients forget to skip their dose, and have no noticeable blunting or delayed psychedelic effect, and clients who saw a delay but no blunting of the experience
