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Although mutation of C438 did not alter the PAM activity of BETP or compound 2 (Ref 27 ), it cannot rule out possible formation of a covalent adduct at C438 in our compound 2-bound GLP-1R structure

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Clinical trials of Ozempic demonstrate that gastroesophageal reflux disease occurred in 1.9% of patients taking 0.5 mg Ozempic and 1.5% of those taking 1 mg Ozempic compared to 0% with placebo

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