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Funding This work was supported by National Institutes of Health Grants R01-DK-114663, P01-HL-62222 and endowed McIntyre Professorship to K.P

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These CVOT findings are supported by a real-world study performed in over 3 million patients with T2DM from the United States, in which patients treated with SGLT2is did not have a higher risk of any or lower amputation compared with incretins or other glucose-lowering agents [77]

Long-term success is often linked with: adequate protein intake preserving muscle mass resistance exercise walking and movement realistic meal structure sleep support stress management emotional awareness flexible habits avoiding extreme dieting The most sustainable progress usually comes from gradual change

This phase also initiates the synthesis of findings to address the research question(s)

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