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These usually reduce over time as the body adjusts to the medication

over the course of a 15 month period [2]

You need to look at what happens inside the body at these doses

Side-effects and tolerability Both medicines cause digestive side-effects, but not always in the same way

Paulus WJ, Tschpe C (2013) A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation

Compounding advocates say that, although the drugs are not FDA-approved, they are still subject to rigorous quality control, in part due to post-2012 rule changes