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Semaglutidethe active ingredient in both Wegovy and compounded formulationsactivates GLP-1 receptors that regulate appetite and blood sugar

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Using both immortalised and primary human cells, liraglutide, acyl-GIP, and a dual GLP-1/GIP receptor agonist (MAR709) failed to produce measurable effects on lipid accumulation, fibrogenic gene expression, or CREB phosphorylation at physiologically relevant concentrations

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doi: 10.1172/jci.insight.140532 318 KnerrPJMowerySAFinanBPerez-TilveDTschpMHDiMarchiRDet al

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These occur because the medications slow down stomach emptying and affect gut hormones

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