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Sustained improvement in non-invasive biomarkers (alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), serum markers of fibrosis (FIB-4, AST to platelet ratio index [APRI]), and liver stiffness (FibroScan vibration-controlled transient elastography [VCTE]) were associated with changes in histologic fibrosis

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M., Davy, K

Thus, these results may underestimate changes associated with tirzepatide in current clinical practice

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While this effect contributes to the appetite-suppressing benefits of the medication, it can initially cause feelings of fullness, queasiness, and general digestive discomfort