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Common First-Dose Experiences and What Is Normal Mild nausea is reported by approximately 25% to 35% of patients starting semaglutide, typically appearing within the first 24 to 72 hours and resolving within days as your body adapts

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Retatrutide (LY-3437943) Clinical Trial Data

Some patients also experience loss of appetite and rapid weight loss, raising concerns about potential nutritional deficiencies [58]

A total of 28 259 were excluded for the following reasons