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According to the FDA prescribing information, this active ingredient (empagliflozin) causes the kidneys to excrete 50-90 grams of extra glucose daily through urine, creating a caloric deficit of 200-300 calories

doi:10.1016/j.diabres.2015.12.022 92

Clinical guidelines recommend a dose escalation of a minimum every 4 weeks to minimize gastrointestinal adverse reactions

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The cardiovascular benefit extends beyond lipid numbers, as these medications also reduce inflammation markers linked to heart disease risk