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95% CI 0.610.79) (196)

Unfortunately, the addition of dapagliflozin to critically ill patients did not improve clinical outcomes but also did not cause harm

Since there are many patients with T2D that cannot be controlled by previously developed drugs, it has been necessary to develop new drugs, one of which is a glucagon-like peptide-1 (GLP-1) based therapy

10.1001/jama.2016.10260 53 MarsoS

This class of drugs was first developed in the 1990s when scientists identified a hormone-like molecule in the venom of a Gila monster, a lizard native to the American Southwest, that stimulated insulin secretion

Early trial data suggest retatrutide could lead to greater average weight loss than tirzepatide, but its long-term safety, side effects, and real-world tolerability are still being studied